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DMHA (Octodrine)
Quick DMHA (Octodrine) Summary Points

  • DMHA or Octodrine is a similar stimulant compound to that of DMAA and AMP Citrate.
  • Mostly a synthetic compound, it offers similar effects to DMAA boosting energy levels, focus, concentration and appetite suppression.
  • It shares a similar structure to the nasal decongestant drug tuaminoheptane, which is banned for use in sport.
  • Few supplements contain this new and novel stimulant, but it will probably become more common in pre workout supplements and fat burners.

What is DMHA (Octodrine)?

DMHA or dimethylhexylamine is a stimulant compound that also goes by some other names such as 2-aminoisoheptane or octodrine. If you’re just talking about 2-aminoisoheptane, there’s actually two forms of the compound including:

  • 2-amino-6-methylheptane
  • 2-amino-5-methylheptane

You’ll find that the “6” form is more commonly used these days simply due to more research and the fact that it costs less. It is considered by most to be a suitable alternative to previous stimulants such as AMP Citrate, BMPEA and DMAA.

Where does DMHA (Octodrine) come from?

Looking at the lower cost DMHA or 2-amino-6-methylheptane, this ingredient looks to be completely synthetic. While previously thought to be naturally derived from a plant known as Aconitum Kusnezoffii, which is actually highly toxic, with its posions often used for hunting purposes. As such, to avoid any dangerous contamination, it is believed that any inclusion of DMHA is synthetic in nature.

If however, you look at the other version of 2-aminoisoheptane (2-amino-5-methylheptane), it is naturally found in Walnut Bark extract, or the bark from the Juglans Regia tree. However, as previously mentioned, it is too economically unviable to utilise this version of the compound as the key stimulant.

DMHA (Octodrine) Benefits

While very few studies have examined the effects of DMHA or Octodrine, due to its similarity in structure to compounds such as DMAA, DMBA and tuaminoheptane, it is often considered to also exert its influence as a decongestant and bronchodilator. With such structural similarity, there is a very good chance that DMHA shares similar functions such as the support of energy levels, acting as bronchodilators (widening of the bronchi for more air flow), decongestant activity (constricting the blood vessels for decreased swelling and therefore better ability to breathe), enhanced focus and a fairly strong appetite suppressant.

BodybuildingDMHA (Octodrine) Benefits for Bodybuilding

From the list of the above potential benefits of DMHA, you can see that a lot of those are applicable to the bodybuilding and weight training setting. Perhaps the best facet of DMHA that can be used for lifting is its ability to boost energy levels and enhance focus and attention. In addition, its hold similar structure to compounds which are seen as monoamine releasing agents. That is, it can potentially increase the levels of monoamines such as dopamine and noradrenaline. This can further support motivation and desire to train. Animal studies have also shown it that DMHA or Octodrine does have the capacity to increase the pain threshold. If this effect was seen in humans as well, it can definitely support more intense workouts and decrease the RPE (rate of perceived exertion). Basically, less fatigue, more work, greater results.

Because strong stimulants are also excellent appetite suppressants, DMHA can potentially also be used to help support fat loss by minimising your desire to snack and possibly straying from your diet. It’s very important to note that while DMHA isn’t a banned substance per se in sport, because of its structural similarity to already banned substances, it’s best not to take any during competition.

DMHA (Octodrine) Side Effects, Safety & Negatives

Due to lack of human research, there’s really no data detailing DMHA’s safety or potential side effects. As such, we can only infer potential side effects due to its structural similarity to DMAA and tuaminoheptane. These effects include increased heart rate, increased blood pressure and possibly shortness of breath. With any supplement that contains a stimulant or a under researched compound, it's best to start with very conservative amounts. For athletes and those who are drug tested quite often, it’s best to stay away from the compound entirely.

DMHA (Octodrine) Recommended Dose & Ingredient Timing

No official dosing recommendations have been set for DMHA, however based on animal studies and similarities to DMAA, a conservative safe dose would be 1mg/kg of bodyweight up to 160mg. The LD50 (dose required to kill half of all test animals) of DMHA to mice is 59mg/kg. Again, it’s best to stick with conservative doses for now and ideally, more research should be conducted before wider release in supplements. Timing wise, it’s best to take 30-60 minutes prior to a workout to help enhance facets of training, while it can also be taken throughout the day as an appetite suppressant.

DMHA (Octodrine) Supplements

With DMAA and AMP Citrate already phasing or phased out of current supplements, you may expect DMHA to start appearing as the alternative. As such, you’ll likely see them in pre workout supplements and fat burners. However, time is still too early to tell if this ingredient will take off or also be banned.

Stacking DMHA (Octodrine)

DMHA or Octodrine can be stacked with a variety of other supplements. Combine it with a protein, BCAA, creatine or intra workouts to further enhance training results. Alternatively you can use it in conjunction with stimulant free fat burners and pre workouts as well. Avoid using it together with any supplements with a high stim content to avoid overstimulation and heightened negative side effects. 

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