What is Pyruvate?
Pyruvate is an organic acid involved in the energy production pathways in the body. It is produced from glucose, and can then be converted back in carbohydrates or into fatty acids for storage.
Where Does Pyruvate Come From?
Pyruvate is produced within the body from glucose. However it can also be found in some foods, including red apples, red wine, cheese and dark beer.
Pyruvate Health Benefits
Pyruvate is currently in the beginning stages of being researched as anti-cancer drug.
Pyruvate Benefits for Bodybuilding
Pyruvate is a relatively effective fat loss supplement, when combined with a slight calorie deficit in the diet. There are numerous studies demonstrating enhanced fat loss compared to the placebo. At higher doses, fat loss can be achieved even with a maintenance level of calories.
Pyruvate Side Effects, Safety and Negatives
Pyruvate is associated with several gastrointestinal side effects, particularly at higher doses. These can include bloating, flatulence and gurgling, and loose stools.
The dosages at which pyruvate is effective tend to be fairly high, meaning that a substantial amount of the supplement would have to be ingested each day to gain the full effects.
Pyruvate Recommended Doses and Ingredient Timing
The optimum dose for fat loss appears to be 20 – 50g of pyruvate daily. It should be noted that pyruvate has a caloric content of its own; and should replace an equivalent number of calories in the diet. The dosage above would replace 10 – 20% calorie intake from carbohydrates.
The lowest effective dose is roughly 6-12g, although studies are divided as to the amount of weight loss that can be achieved at this dose. However, it does limit the side effects.
Unfortunately pyruvate can only be bought in 1000mg capsules, meaning you would have to swallow a fair number of capsules to gain the optimum dose.
Egras AM, et al. An evidence-based review of fat modifying supplemental weight loss products. J Obes. (2011)
Stanko RT, Tietze DL, Arch JE. Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate. Am J Clin Nutr. (1992)
Stanko RT, Tietze DL, Arch JE. Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate. Am J Clin Nutr. (1992)
Stanko RT, et al. Pyruvate supplementation of a low-cholesterol, low-fat diet: effects on plasma lipid concentrations and body composition in hyperlipidemic patients. Am J Clin Nutr. (1994)
Ostojic SM, Ahmetovic Z. The effect of 4 weeks treatment with a 2-gram daily dose of pyruvate on body composition in healthy trained men. Int J Vitam Nutr Res. (2009)
Koh-Banerjee PK, et al. Effects of calcium pyruvate supplementation during training on body composition, exercise capacity, and metabolic responses to exercise. Nutrition. (2005)
Kalman D, et al. The effects of pyruvate supplementation on body composition in overweight individuals. Nutrition. (1999)