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AAKG (Arginine Alpha-Ketoglutarate): The Ultimate Guide

Quick Summary

  • AAKG is a combo of amino acid arginine & metabolic intermediate alpha-ketoglutarate
  • Highly regarded as a pre-workout supplement
  • Boosts energy, enhances muscle pump, & maintains muscle strength
  • Arginine is a conditionally essential amino acid sourced from various foods
  • AKG is pivotal in the Krebs cycle for energy production
  • AAKG promotes improved blood flow to muscles
  • Arginine aids in waste removal, bolsters immune function, speeds up wound healing, fuels creatine production, & might elevate growth hormone levels
  • AKG supports energy generation, glutamine production, detoxifies ammonia, & has antioxidant properties
  • Bodybuilders love AAKG for its vasodilatory properties & energy support
  • Some side effects include stomach discomfort, dizziness, or headaches
  • Recommended dose: 3-6g before a workout
  • AAKG can be standalone or mixed in pre-workout blends
  • Works well when stacked with most supplements including beta-alanine, carnitine, BCAAs, or protein powders

Dive Deeper into AAKG

What's AAKG?

Arginine alpha-ketoglutarate, known as AAKG, is a fusion of amino acid arginine & metabolic alpha-ketoglutarate. Widely preferred by fitness aficionados, it amplifies workouts by bolstering energy, ensuring muscle pump, & conserving muscle structure.

AAKG's Roots

Arginine, although produced in-house in limited capacities, is mainly derived from protein-rich foods like meat, dairy, nuts, & seeds. Meanwhile, alpha-ketoglutarate (AKG) holds its fame in the Krebs cycle, our cells' primary energy pathway.

AAKG's Array of Benefits:

  • Arginine’s Contributions: More than a foundational amino acid, arginine is instrumental in producing nitric oxide, boosting muscle blood flow. It's also pivotal in waste management, enhancing immune functions, accelerating wound recovery, & potentially spiking growth hormone levels.
  • The Might of AAKG: Recognised for its role in the Krebs cycle, AAKG is central to energy dynamics. It's essential for glutamine production & plays roles in detoxification & antioxidation.

Bodybuilding & AAKG

The perks of AAKG aren't lost on bodybuilders. Its vasodilatory capabilities ensure muscles receive nutrients efficiently & dispel waste rapidly, allowing for sustained & more intense workouts.

Safety, Side Effects, & Recommendations

While AAKG is largely considered safe, some might feel side effects like stomach upsets or dizziness. Although many testimonials praise AAKG, scientific evaluations give varied conclusions.

To leverage AAKG's full potential, take 3-6g roughly 30 minutes pre-workout. Exceeding a 10g single dose might be counterproductive.

Sourcing & Stacking AAKG

For those in Australia seeking a premium AAKG powder, Elemental Nutrition AAKG stands out. While it can be a standalone supplement, it synergizes well with enhancers like beta-alanine, carnitine, BCAAs, or protein powders.


In the realm of fitness supplements, AAKG offers enhanced workouts & energy boosts, with its benefits deeply rooted in nutrition & cellular pathways. While research on its efficacy varies, many swear by its results.

Australians seeking premium AAKG can turn to Elemental Nutrition AAKG. As always, it's essential to use supplements wisely in line with individual health & fitness needs.


(1) Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res. 1999 Aug 15;43(3):521-31.
(2) Witte MB, Barbul A. Arginine physiology and its implication for wound healing. Wound Repair Regen. 2003 Nov-Dec;11(6):419-23.
(3) Alba-Roth J, Müller OA, Schopohl J, von Werder K. Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9.
(4) Hares, P; James, IM; Pearson, RM Effect of ornithine alpha ketoglutarate (OAKG) on the response of brain metabolism to hypoxia in the dog.".Stroke; a journal of cerebral circulation (May–Jun 1978). 9 (3): 222–4.
(5) Long, L; Halliwell, B "Artefacts in cell culture: α-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media.". Biochemical and biophysical research communications. (2011) 406 (1): 20–24.
(6) Prosser JM, Majlesi N, Chan GM, Olsen D, Hoffman RS, Nelson LS. Adverse effects associated with arginine alpha-ketoglutarate containing supplements. Hum Exp Toxicol. 2009 May;28(5):259-62.
(7) Willoughby DS, Boucher T, Reid J, Skelton G, Clark M. Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise. Int J Sport Nutr Exerc Metab. 2011 Aug;21(4):291-9.
(8) Greer BK, Jones BT. Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training. J Strength Cond Res. 2011 Jul;25(7):1789-94.

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