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Colforsin
Colforsin is an extract from the roots of the coleus forskohlii plant. Colforsin has been used for hundreds, if not thousands of years in Aruvedic medicine, Western scientists only became interested in it in the mid 1980's when they began to use the compound to treat cardiovascular disease, mainly through its vasodilatory effect.
HOW IT WORKS: As a cyclic AMP stimulator, colforsin, through a series of steps, leads to the production of something called hormone sensitive lipase, or HSL. This compound in turn breaks stored fat down into triglycerides that can be used by the body as fuel. The latter, in combination with its stimulation of thyroid functions, could mean that colforsin, in addition to a whole bunch of other functions, might also cause decrease body fat. Now you of course remember ephedrine as being an adrenergic alpha and beta-receptor agonist, which meant that it also stimulated cardiac tissue and raised blood pressure, hence all the complaints about ephedrine-related heart problems. Colforsin, however, is what's known as a post-receptor agent. That means that it bypasses adrenergic receptor activation and directly activates cyclase activity without the negative side effects of ephedrine. That means fat loss without the problems. Furthermore, this post-receptor agent increases nitrogen retention, which is one of the mechanisms attributed to anabolic steroids and other muscle-building agents. And because it's a post-receptor agent, the effects won't down regulate over time. Another property that piqued the curiosity of researchers, was that increases in CAMP cause luteinizing hormone (LH) to be released, which then prompts the Leydig cells in the testes to secrete Testosterone.
So to synopsize, colforsin seemed to have the following effects on body composition:
• Increase in TSH, which leads to an increase in metabolic rate
• Increase in HSL, which leads to triglycerides being released and burned as fat
• Increase in cyclase activity, which causes fat to be burned
• Increase in CAMP, which causes the Leydig cells to produce Testosterone
• Increase in nitrogen retention, which causes an increase in muscle mass
THE STUDY: To find out, Kansas State University researchers Godard, Johnson, and Richmond recruited 30 obese men. The aim of the study was to find if colforsin caused an increase in endogenous andrenergic hormone levels; an increase in resting metabolic rate; and a favorable impact on body composition. The trial lasted 12 weeks. Fifteen men received one tablet of colforsin in the morning and one tablet 6 to 8 hours later. The other 15 men followed the same regimen, albeit with a placebo. Body composition tests were performed by DEXA analysis and body circumference measurements.
THE RESULTS: Fat Mass: The colforsin group lost 4.52 kilograms (9,94 pounds) of fat, plus or minus 5.74 kilograms, while the placebo group lost only 0.51 kilograms (1.12 pounds), plus or minus 1.91 kilograms. Lean Body Mass: The colforsin group gained 3.71 kilograms of lean body mass (8.162 pounds), plus or minus 4.07 kilograms, while the placebo group gained 1.57 kilograms (3.45 pounds), plus or minus 2.56 kilograms. Testosterone: The Testosterone of the colforsin group rose 33.7 percent, while it decreased 18.35 percent in the placebo group. Bone Mass: The bone mass of the colforsin group increased significantly compared with the placebo (p < or = 0.05).
DISCUSSION: Despite no change in diet, the group using colforsin experienced remarkable gains in lean body mass. How remarkable? Consider that another 12-week study using the anabolic steroid Anavar resulted in test subjects gaining approximately 3.9 pounds of lean mass. That's good, right? But the subjects in the colforsin study gained 8.2 pounds of lean mass in the same amount of time! And don't forget the impressive losses of body fat. Again, subjects in a study using Anavar experienced a loss of 7.0 pounds of body fat in 12 weeks, while those using colforsin experienced a loss of 9.9 pounds! Granted, the dosage of Anavar used in the study was only 20 mg. a day, but regardless, colforsin proved more anabolic and more effective in burning fat. The researchers in the colforsin study credited the fat losses to some of the aforementioned properties of colforsin (ability to mimic TSH, CAMP mediated rise in HSL, and post-receptor increases in metabolism), while they credited the amazing gains in lean body mass to increased nitrogen retention.
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