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- Nitrosigine® (also known as Nitrosine) is a patented inositol-stabilised arginine silicate that boosts nitric oxide levels.
- It enhances blood flow, muscle pumps, endurance, and cognitive performance.
- Unlike plain L-arginine, Nitrosigine delivers longer-lasting circulation effects.
- Clinically effective dose: 1.5g (1500mg) per serving, taken 30–45 minutes before training.
- Ideal for both stimulant and stim-free pre-workouts.
- Popular Nitrosigine pre-workouts in Australia include Ghost Pump, Rule 1 R1 Pump, and Onest HyperLoad.
- Safe, non-stimulant, and stackable with other pump ingredients like Citrulline and VASO6®.
- Perfect for athletes and gym-goers chasing improved pumps, focus, and performance.
What is Nitrosigine®?
Nitrosigine® (sometimes called Nitrosine) is a patented form of inositol-stabilised arginine silicate developed by Nutrition 21. It boosts nitric oxide (NO) production, leading to greater blood flow, muscle pump, endurance, and focus. Unlike regular L-arginine, it remains stable in the body and delivers lasting NO benefits—making it one of the most effective modern pump ingredients.
How Nitrosigine® Works
Nitrosigine combines arginine, silicon, and inositol to create a complex that supports longer NO production and blood flow. Clinical research shows it significantly increases flow-mediated dilation (FMD), improving circulation and nutrient delivery. Users report better muscle fullness, vascularity, endurance, and sharper mental focus thanks to improved oxygen and nutrient transport.
Key Benefits
- Powerful muscle pumps and vascularity.
- Better nutrient delivery and faster recovery.
- Improved mental focus and performance.
- Non-stimulant and stackable with other pre-workout ingredients.
- Clinically validated at just 1.5g per serve.
Dosage & Timing
The recommended dose of Nitrosigine is 1.5g (1500mg) per serving, ideally taken 30–45 minutes before exercise. Because it’s non-stimulant, it suits both morning and evening training. It also pairs well with stimulants like caffeine or endurance ingredients such as Beta-Alanine and Citrulline.
Top Nitrosigine® Supplements in Australia
Ghost Pump
A stim-free pre-workout featuring the full 1.5g Nitrosigine dose alongside Citrulline and Taurine. Designed for massive pumps and vascularity without caffeine.
Rule 1 R1 Pump
A non-stimulant pre-workout using Nitrosigine with HydroMax® and Citrulline for improved circulation, hydration, and endurance.
Onest HyperLoad
A stim-based hybrid pre-workout with 1.5g Nitrosigine, Citrulline, and Beta-Alanine for energy, focus, and powerful blood flow.
How Nitrosigine® Compares
| Ingredient | Typical Dose | Function | Comparison |
|---|---|---|---|
| Nitrosigine® | 1.5g | NO booster, blood flow, focus | Clinically effective at low dose |
| L-Citrulline Malate | 6–8g | NO booster, endurance | Requires higher dose, slower onset |
| VASO6® | 300mg | Polyphenol vasodilator | Works synergistically with Nitrosigine |
| Beetroot (Nitrates) | 500–1000mg nitrate | Oxygen efficiency, stamina | Best for endurance events |
Safety & Side Effects
Nitrosigine is well tolerated in healthy adults. It is non-stimulant and free from jittery side effects. Always check full product labels for stimulant content or other vasodilators. Individuals on blood pressure or heart medications should consult their healthcare provider before use.
Summary
Nitrosigine® is a research-backed nitric oxide enhancer proven to increase pump, focus, and endurance. The 1.5g dose is the gold standard across leading products in Australia. For superior performance, look for pre-workouts that clearly list this amount.
- Ghost Pump – Stim-free formula for late-night or caffeine-sensitive training.
- Rule 1 R1 Pump – Hydration, pump, and circulation support in a non-stim format.
- Onest HyperLoad – Hybrid stim + pump formula delivering energy and vascularity.
Whether you’re chasing skin-splitting pumps, improved endurance, or sharper focus, Nitrosigine stands as one of the most reliable and scientifically supported nitric oxide boosters on the market.
References
- Jagim AR, et al. "The acute effects of inositol-stabilized arginine silicate and citrulline malate on vasodilation." Journal of Exercise and Nutrition. 2020;3(4):1–8.
- Nutrition 21. "Nitrosigine® Scientific Summary." Internal Data Report, 2023.
- Goudarzian M, et al. "Comparative analysis of nitric oxide donors in resistance training." Sports Medicine Open. 2021;7(2):105–113.
- PricePlow Research Team. "Nitrosigine overview and synergy with citrulline." 2023; Internal Review Report.