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MusclePharm have skyrocketed to success recently in the last few years. They have built their name around supporting the performance of some of the world’s best athletes in a manner that is safe, legal, and effective. Many are already familiar with the hugely popular all in one pre workout supplement, MusclePharm Assault. However, MusclePharm have recently proved that they are not a one hit wonder by adding to their pre workout line up with MusclePharm Hybrid NO.

What is MusclePharm Hybrid NO?

MusclePharm Hybrid NO is a stimulant free, capsule based, pre workout nitric oxide (NO) booster (AKA stim-free pre workout supplements). It primarily places focus on increasing muscle pumps, increasing muscle fullness and vascularity, and to maximise vasodilation. This may improve your workout performance so you can get the most out of it.

MusclePharm Hybrid NO First Impressions

On first impressions, MusclePharm Hybrid NO is definitely an interesting product. It contains a combination of ingredients that are known to increase NO production. Of these, the best known is possibly citrulline malate, a very popular and common ingredient in modern pre workout supplements, that is quickly replacing arginine. Agmatine is another common ingredient used in modern pre workout supplements. This ingredient has many potential benefits, some of which buffering pain, improving muscle-mind connections, and increasing vasodilation (Molderings et al, 2011). Also included is Gycocarn, a patented form of glycine propionyl-L-carnitine (better known as GPLC). This compound is also known for its ability to increase NO production (Bloomer et al, 2009) and its associations with increased exercise performance (Jacobs et al, 2009).

Of Particular Interest

In addition to the more common ingredients listed above, Hydrid NO also contain a blend of potentially herbal ingredients that also show huge promise in promoting NO production and pump. The first and most well-known botanical is beet root extract. This is an ingredient very quickly finding its way into all the best pre workout supplements. Beetroot and its extracts have been shown to increase NO levels (Bailey et al, 2010). In addition to this there is rutaecarpine, a powerful vasodilator (Jayakumar & Sheu, 2011), as well as Hawthorne Berry for supporting heart health (Guo et al, 2009).

Difference from the Competition

MusclePharm Hybrid NO is one of the few stim-free pre workouts on the market. If you’re looking for stim-free pre workouts, it’s often hard to find a good one, especially from one of the more well-known manufacturers. It’s therefore excellent to see that a giant such as MusclePharm are acknowledging this demand.

Flavour & Mixability

MusclePharm Hybrid NO comes in two flavours; Cherry Limeade and Fruit Punch. They both have quite an sour note, which is largely due to the GPLC content. However they are still relatively pleasant to consume. One can mix it in with fruit juice to further tone down the sourness.

Negatives

MusclePharm has done a great job in focusing in on NO synthesis and muscle pump by throwing together so many effective NO boosters. However there’s really a limit in how much you can squeeze into a capsule. Consequently, a serving size of Hybrid NO is 4 caps, quite a few for some people. It may have been simpler if Hybrid NO was just a power, which would mean that MusclePharm would add in even more pre workout ingredients such as the ever so popular beta alanine and creatine.

Who is Muscle Pharm Hybrid NO for?

MusclePharm Hybrid NO is suitable for anyone looking to get the most out of their workout without stimulants. If you are working out late, Hybrid NO will be suitable because it is far less likely to interfere with your sleep. Additionally, if you are using a strong thermogenic fat burner before a workout, it is often not recommended that stimulant based pre workouts should be used. However, Hybrid NO would be perfectly stackable with thermogenics, and even some other pre workout supplements. The capsules also contain negligible calories, which would make it suitable for people at any phase of their training.

Bailey et al (2010), Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. Journal of Applied Physiology 109: 135-148
Bloomer (2009), Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Int J Vitam Nutr Res, 79: 131-141
Guo et al (2009), Hawthorn extract for treating chronic heart failure. Hawthorn extract for treating chronic heart failure. Cochrane Database of Systematic Reviews, DOI: 10.1002/14651858.CD005312.pub2
Jacobs et al (2009), Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr, 2: 9
Jayakumar & Sheu (2011), Cardiovascular Pharmacological Actions of Rutaecarpine, a Quinazolinocarboline Alkaloid Isolated From Evodia rutaecarpa. Journal of Experimental & Clinical Medicine, 3: 63-96
Molderings GJ, Haenisch B. ‘Agmatine (decarboxylated L-arginine): physiological role and therapeutic potential.’ Pharmacol Ther. 2012 Mar;133(3):351-65. Epub 2011 Dec 22.

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