Quick Growth Hormone Summary Points
- Growth hormone is a naturally occuring hormone in the body, which is released in a pulse like manner throughout the day
- Growth hormone secretion decreases steadily from the age of 30 and can be decreased by up to 60% by the time you're 60
- This decrease in GH will result in increased fat, less muscle and reduced training capacity
- Studies have shown that certain mixtures of amino acids can help support and optimise GH levels.
- These amino acids include arginine, lysine and ornithine
- GH Support supplements often contain these amino acids along with other ingredients to optimise training and results.
What Are Growth Hormones?
Human Growth Hormone (HGH) is an amino acid protein or peptide naturally released from the pituitary gland. Growth Hormone (GH), is released in a pulsatile manner, occurring every 2-3 hours. On a daily basis, we get about 8-12 doses of growth hormone, which add up to 0.5 mg of GH per day. GHRH (growth hormone releasing hormone) controls the pulsatile release of HGH, and somatostatin counteracts this. When GHRH is high and somatostatin is low, a spike in blood levels of GH occurs. Once this GH pulse occurs, blood GH affects tissues resulting in stronger and longer bones, protein building, loss of fat, and control of body water. Unfortunately around the age of 30, a progressive decline in GH secretion from the pituitary occurs. By the age of 60, GH production can have declined by 60%, meaning that an the prior release of 0.5 mg of GH per day has diminished to a mere 0.2 mg each day, equal the level of young adults. ‘Somatopause’ is the term by researchers use to describe this condition, which can be aided through GH replacement therapy. When a GH deficiency occurs, adults suffer from increased fat, especially around the midsection, and reduced lean body mass (muscle) and bone mineral composition. These negative body composition changes unfortunately result in decreased strength in the muscles, reduced capacity for exercise and training, and a relatively poorer power output.1
Amino Acids & HGH
In a study of 15 males to evaluate the secretion of growth factors following stimulation by oral amino acids, the results showed that supplementation of the amino acids 1-lysine (1200 mg) and 1-arginine (1200 mg) caused a release of somatotropin and insulin in the pituitary. Interestingly, when administered alone, neither of the above amino acids demonstrated stimulating activity on the pituitary.2 No other supplement has demonstrated equivalent effectiveness to the arginine pyroglutamate and lysine combination. When both arginine pyroglutamate and lysine were taken individually, even in large doses, they were not effective. It is the specific combination of arginine pyroglutamate and lysine, taken in the proper ratio, which makes a very effective GH releaser. Lysine, or L-lysine, is an essential amino acid, meaning that it is necessary for human health but cannot be made by the body. For this reason, lysine must be obtained from food. Lysine is important for proper growth, and it plays an essential role in the production of carnitine, a nutrient responsible for converting fatty acids into energy and helping to lower cholesterol. Lysine helps the body absorb and conserve calcium, and it plays an important role in the formation of collagen, important for strong bones and connective tissues. A lysine deficiency can cause fatigue, loss of appetite, agitation, slow growth, anemia, and other issues. Arginine pyroglutamate, is an excellent growth hormone releaser because it is carried more efficiently across the blood-brain barrier than arginine alone. Arginine pyroglutamate is an arginine molecule combined with a pyroglutamate molecule.
As has been shown in the study discussed above, GH supplementation with the specific combination of arginine pyroglutamate and lysine, taken in the proper ratio, may makes an effective GH releaser. The benefits of GH release include muscle building and fat loss, making it a worthwhile supplement for anyone wanting to achieve results in, and out of the gym. GH supplements of this nature may also include constituents as follows for designed by supplement manufacturers to further improve effectiveness. ZMA, Tribulus and Eurycoma Longofolia (for their ability to support & or increase testosterone levels safely and naturally), Fenugreek (to enhance absorption), and Niacin/Vitamin B3 and B6/pyridoxine (to help the metabolism of proteins, carbohydrates and fats). Without GH performing its role, your psychological state, body composition, muscular performance, and cardiac performance may suffer. As well as arginine pyroglutamate and Lysine, commonly found GH supplements also include glutamine, ornithine and GABA as they also are believed to promote natural Growth Hormone release.
1The Fountain of GH - Does it work? By Dr. John M Berardi, Ph.D.
2 A study of growth hormone release in man after oral administration of amino acids., Isidori A, Lo Monaco A, Cappa M.
3 The Fountain of GH - Does it work? By Dr. John M Berardi, Ph.D.