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Elemental IGF-1

Elemental IGF-1

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150g / 30 Serves
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150g Natural Flavour ($59.95)
Elemental IGF-1

Elemental Nutrition IGF-1 is an advanced supplement for hardcore bodybuilders and athletes looking for the ultimate edge in strength and muscle development. Elemental Nutrition IFG-1 is designed to promote anabolism by increasing IGF-1 levels in the body so as to maximally stimulate muscle protein synthesis in response to exercise.

Rich in Bioactive Growth Factors

Elemental Nutrition IGF-1 is packed with one of the highest grades of colostrum available. Containing a minimum immunoglobulin content of some 40%; Elemental Nutrition IGF-1 is rich in insulin-like growth factors (i.e., IGF-1 & IGF-2), transforming growth factors (i.e., TGF-Beta1 & TGF-Beta2) and immunoglobulins. These components make Elemental Nutrition IGF-1 an ideal supplement for anyone undertaking periods of high-intensity training and/or looking to increase lean body mass. Take yourself to the next level with Elemental Nutrition IGF-1.

Transforming Growth Factors (TGF)

The colostrum in Elemental Nutrition IGF-1 is rich in transforming growth factors beta1 & 2 (TGF-b). TGF-b are signalling molecules that appear to be central for tendon growth and adaptation12. For instance, during embryonic development, TGF-b signalling is required for proper development of limb tendons13-15. In addition, whenever an individual undertakes any kind of acute mechanical loading such as occurs in weight training, active TGF-b is released from tendons16. As such, TGF-b is believed to mediate many of the anabolic pathways that control exercise-mediated tendon growth and adaption12, 17. For this reason, supplementation with Elemental Nutrition IGF-1 may be useful in individuals with tendon injuries or engaged in high load resistance exercise.

IGF-1 FunctionsIGF-1 Functions and Actions Diagram

As shown on the diagram to the right, IGF-1 power is produced mainly in the liver in response to growth hormone stimulation and is the key mediator of growth hormones powerful effects. You can have oodles of growth hormone, but if that doesn’t translate into meaningful increases in IGF-1, then it’s pretty much useless. This is why increasing IGF-1 levels in considered a more specific and direct means of boosting anabolism.

IGF-1 Levels in the Body

IGF-1 levels are initially low at birth and increase with age up to the age of 20 years, where after they decline gradually1. While genetic factors can account for a large degree of variation in IGF-1 levels2, 3, nutrition plays an important role, with IGF-1 levels accurately reflect nutritional status4. Research has shown IGF-1 levels reliably decline during starvation or calorie restriction and then rise again following refeeding5-8. In terms of its interaction with other hormones, IGF-1 levels are boosted by thyroid and testosterone hormones, while estrogen blunts IGF-1 secretion9.

IGF-1 Muscle Growth

When it comes to bodybuilding and resistance exercise, IGF-1 is considered one of the most potent anabolic compounds in the body. It is known to simultaneously enhance protein synthesis and inhibit protein breakdown and is actually considered the most important mediator of muscle growth in the body10-11. Conversely low IGF-I concentrations favour protein catabolism in skeletal muscle, releasing amino acids into the circulation for breakdown in the liver4.

IGF-1 and Insulin

IGF-1 or insulin-like growth factor-I was named because its structure and metabolic function simulate insulin4. In fact, insulin is required for the synthesis of IGF-I in the liver and insulin can actually stimulate IGF-I secretion independently of growth hormone. Lastly insulin inhibits the synthesis of two important protein called IGF-binding proteins, which as their name suggests – bind IGF-1, thus reducing free IGF-I and therefore its bioactivity4. In this way, insulin enhances both IGF-I levels and bioactivity. For these reason, it’s important to take Elemental Nutrition’s IGF-1 as part of a protein and carbohydrate meal so as to maximise insulin response and therefore IGF-1 bioactivity.

References
1. Yu H, et al. Insulin-like growth factors (IGF-I, free IGF-I, and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation. J Clin Lab Anal. 1999;13:166–172.

2. Hong Y, et al. Quantitative genetic analyses of insulin-like growth factor-I (IGF-I), IGF-binding protein-1 and insulin levels in middle-aged and elderly twins. J Clin Endocrinol Metab. 1996;81:1791–1797.
3. Harrela M, et al. Genetic and environmental components of inter-individual variation in circulating levels of IGF-I, IGF-II, IGFBP-1 and IGFBP-3. J Clin Invest. 1996;98:2612–1615.
4. Livingstone C. Insulin-like growth factor-I (IGF-I) and clinical nutrition. Clinical Science. 2013;125: 265–280.
5. Clemmons DR,et al. Reduction of plasma immunoreactive somatomedin C during fasting in humans. J Clin Endocrinol Metab. 1981;53:1247–1250.
6. Gomez JM, et al. The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat. Growth Horm IGF Res. 2004;14:91–96.
7. Hintz RL, et al. Plasma somatomedin and growth hormone values in children with protein calorie malnutrition. J Pediatr.1978;92:153–156.
8. Hill K, et al. Serum insulin-like growth factor-I concentrations in the recovery of patients with anorexia nervosa. J Am Coll Nutr.1993;12:475–478.
9. Miell JP, et al. Effects of hypothyroidism on insulin-like growth factors (IGFs) and growth hormone- and IGF-binding proteins. J Clin Endocrinol Metab. 1993;76:950–955.
10. Clemmons DR. Role of IGF-I in skeletal muscle mass maintenance. Trends Endocrinol Metab. 2009;20:349–356.
11. Goldspink G. Loss of muscle strength during aging studied at the gene level. Rejuvenation Res. 2007;10:397–405.
12. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev. 2004;84:649–698.
13. Lorda-Diez CI, et al. Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme. J Biol Chem. 2009;284:29988–29996.
14. Murchison ND, et al. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development. 2007;134:2697–2708.
15. Pryce BA, et al. Recruitment and maintenance of tendon progenitors by TGFβ signaling are essential for tendon formation. Development. 2009; 136:1351–1361.
16. Heinemeier K, et al. Role of TGF-β1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue. J Appl Physiol2 2003;95:2390–2397.
17. Holladay C, et al. Preferential tendon stem cell response to growth factor supplementation. J Tissue Eng Regen Med. 2014 Jan 29. doi: 10.1002/term.1852. [Epub ahead of print]

Supplement Facts
Elemental Nutrition IGF-1
Serving Size
Servings Per Container
Formulated Supplementary Sports Food
5g
30
Nutritional Information
Per Serve
Per 100g
Energy
81.5kJ
2Cal
1630kJ
390Cal
Protein
4.3g
87g
Fat - Total
0.1g
2.2g
- Saturated
0.1g
1.0g
Carbohydrates - Total
0.3g
5.8g
- Sugar
0.2g
3.7g
Sodium
6.0mg
120mg
Bio-Active Factor Profile
Immunoglobins
IgG
1838.2mg
36763mg
IgA
61.6mg
1231.9mg
Growth Factor
IGF-1
15.5μg
310.4μg
IGF-2
3.4μg
67.9μg
TGF-Beta1
1.0μg
19.4μg
TGF-Beta2
11.2μg
223.1μg
Lactoferrin
150mg
3000mg
Other Ingredients
Pure Bovine Colostrum IgG40, Lactoferrin 95%
Elemental Nutrition IGF-1 Directions
Scoop it, Shake it, Drink it! Take 5g in 200mL of milk/protein shake, water or fruit juice.
Storage
Replace lid immediately and store in cool dry place below 30°C away from sunlight.
Warning
This product is not a sole source of nutrition and should be used in conjunction with an appropriate physical training or exercise programme. Not suitable for children under 15 years of age or pregnant women. Should only be used under medical or dietetic supervision.
General Product Warning
Users should seek medical advice prior to beginning any supplementation program. This especially applies to individuals taking prescription medication or those with pre-existing medical conditions. Always read the label prior to consuming any supplement, always follow the manufacturer's directions & never exceed the recommended dose. In the event of experiencing any unwanted effects discontinue use immediately & seek medical advice if symptoms persist. Keep out of reach of children.
Copyright
Copyright MrSupplement Marketing Pty Ltd 2010-2016. This website, and the images, text and tables on it are subject to copyright under the Australian Copyright Act 1968 (Cth), as well as under the copyright law of other countries by virtue of worldwide treaties, belonging to MrSupplement Marketing Pty Limited and to its suppliers & or product manufacturers. Reasonable portions of this website may be printed out solely insofar as is necessary to order products from the MrSupplement.com.au web site. Any other reproduction or communication in whole or in part is unauthorised and may result in legal proceedings being taken to protect the intellectual property rights of MrSupplement Marketing Pty Limited and/or suppliers & product manufacturers.

Elemental IGF-1 Reviews

, Fraser, ACT on 19/02/2014
Rating:
(4 / 5)
A friend from footy suggested I try this supp to help with a knee injury. A month on, I definitely reckon its made a big difference despite being pretty skeptical it would help in anyway. Highly recommend if trying if your trying to rehabilitate from any ligament/tendon injury.

Elemental IGF-1 Information

Ask a question about
Elemental IGF-1
Name Email Address Ask Question
Can elemental nutrition IGF-1 be taken with elemental nutrition HGH?
Yes, Elemental IGF-1 and HGH will stack well together.
when is the best time of taking this supplement? Can I take it before sleep together with my casein protein shake? Also, I am supplementing with Elemental Nutrition anabolic mass, are they functioning in the same way?
IGF-1 can be taken any time of the day. However, you may find that you have good results if taken at night before sleep. It can be mixed with your casein without any problems. Anabolic Mass does not function the same as it contains a testosterone booster, which is to support a whole different set of hormones. They can therefore be used in the same stack without problem.
I've been using Mr Supplement for over 5 years now and have NEVER had any problems whatsoever. The prices are excellent (and I do check around), the delivery time is unbeatable (and that's regardless of where I am as I move around quite a bit for work) and the product is always of the highest quality. I never write online reviews or testimonials but felt that Mr Supplement have more than earned my words of praise. A BIG thank you to all the team at Mr Supplement who somehow seem to continually improve what is & has always been a well oiled machine. Cheers, Dan
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