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7-Keto
 

7-Keto is a naturally occurring metabolite or breakdown product of the hormone dehydroepiandrosterone (DHEA). DHEA is the most abundant of the adrenal steroid hormones & serves as a precursor for sex hormones, such as estrogen & testosterone1. Earlier studies were able to show that DHEA declines with ageing and may be associated with body fat accumulation and weight gain.2 In addition, by improving levels of DHEA in the body, it may be able to improve insulin resistance.3

The capacity of 7-Keto to promote weight loss in overweight people has also been investigated in a double-blind study4. Participants in the study were advised to exercise three times per week for 45 minutes & to eat an 1,800-calorie per day diet. Each person was given either a placebo or 100 mg of 7-Keto twice daily. After eight weeks, those receiving 7-Keto had lost an average of 2.85Kg, compared with 0.95Kg in the placebo group (a statistically significant difference). In addition, the percentage of body fat decreased by 1.8% in the 7-Keto group, compared with only 0.57% in the placebo group. The increased weight loss in the 7-Keto group was associated with a significant increase in levels of T3 (a thyroid hormone that plays a major role in determining a person’s metabolic rate), although the levels of T3 did not exceed the normal range. 7-Keto may improve lean body mass by increasing DHEA levels and potentially increasing the amount of testosterone. This combined with increasing your body's ability to burn calories has made 7-Keto a popular choice for those looking to reduce body fat, whilst maintaining or improving lean muscle.

7-Keto Supplements are commonly presented & sold as Complementary Medicines, Registered Therapeutic Items or Goods and Formulated Supplementary Sports Foods in Australia. 7-Keto is not a sole source of nutrition and should be used in conjunction with an appropriate physical training or exercise programme. Not suitable for children or pregnant women. Should only be used under medical or dietetic supervision. Always read the label prior to use.

1. William F Ganong MD, 'Review of Medical Physiology', 22nd Ed, McGraw Hill, 2005, page 362.
2. De Pergola G, Zamboni M, Sciaraffia M, Turcato E, Pannacciulli N, Armellini F, Giorgino F, Perrini S, Bosello O, Giorgino R: Body fat accumulation is possibly responsible for lower dehydroepiandrosterone circulating levels in premenopausal obese women. Int J Obes Relat Metab Disord 1996, 20(12):1105-10.
3. Rabijewski M, Zgliczyński W. ‘[Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease--preliminary study].’ Endokrynol Pol. 2005 Nov-Dec;56(6):904-10.
4. Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q: A randomized double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Curr Thera 2000, 61:435-42.
5. Zenk JL, Leikam SA, Kassen LJ, Kuskowski MA: Effect of lean system 7 on metabolic rate and body composition. Nutrition 2005, 21(2):179-85.
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